The hypertension vaccine have be the speciality of a petite US be trained presented this week at a assembly of the American Heart Association's Scientific Sessions 2007, bordered by Orlando, Florida, via install author Dr Juerg Nussberger and colleagues. Nussberger be professor of pills at the University Hospital of the Canton of Vaud, in Lausanne, Switzerland.
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All that mud is for larger grow clinical research to verify the results of the small study that put transmit the vaccine is past the worst and effective.
The vaccine is a non-infectious iota coiled future a virus and chemically concerted beside angiotensin II, a molecule that go down smoothly in the blood and make blood vessel authoritarian, in that channel incentive high blood pressure. The body's immune arrangement responds by attacking the virus, thereby create antibodies resistant angiotensin II.
Drugs that unjustifiable high blood pressure also target angiotensin II, but they perpetrate in view of that either by inhibit its rendition from angiotensin I or by limit it from wharf by the receptors that lead to capillary constriction. They are only effective if kept to a precise height in the blood creek, hence the need to take them every day.
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The researchers treat 72 patients (65 man and 7 women) with balmy to clement high blood pressure by inject them three times with 100 or 300 micrograms of vaccine or placebo. The shot be done at the create of the study (week zero), and subsequent at week 4 and again at week 12. They measured the blood pressure change at week 14. The intermediate age of the patients be 51.5 years.
After the injections, the patients in the vaccine jumble have a athletic antibody reply against angiotensin II, and this response was a great business deal stronger in the patients who had the high dose.
For the patients who were given the 300 microgram vaccine injections (the higher dose), their daytime systolic blood pressure (the higher of the two reading, taken as the heart constricts) was 5.6 mm of mercury (mm Hg) degrade than that of the placebo group. Their diastolic blood pressure (the lower of the two readings, taken when the heart relax relating beats) was 2.8 mm Hg lower than the placebo group's.
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They spiky out another forthcoming profit of the vaccine equate with medication. The vaccine makes anitbodies behave like a "sponge", said Bachmann: "The sponge empty out for the hours of darkness when small angiotensin II is produced, so it is competent to support all the angiotensin II produced early in the morning," he explain.
And this burgeoning industry is competent to operate short the slightest propaganda anyone salaried to it by medical researchers.
Another potential advantage the vaccine has complete drugs is that they burgeon level of the enzyme renin, which cause inflammation and is rumination to increase risk of kidney failure, whereas the vaccine only cause a trivial increase in renin, said the researchers.
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President of the American Heart Association, Dr Daniel Jones said he was prompted by the study's burgeoning findings and original point of view, even if it may be moreover early to clash able to its clinical openness.
Click here for American Heart Association.
Written by: Catharine Paddock
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