Monday, April 7, 2008

Cholesterol-lowering Drugs May Be Useful In An Influenza Pandemic




Recent concern around the expectations of a grave respiratory tract infectivity pandemic enjoy fire up several province to kick off stockpile vaccines and antiviral agents. However, an article within the July aspect of Clinical Infectious Diseases, presently at your disposal online, propose that cholesterol-lowering drugs certain through routine of statins could be courteous, and would be more nigh resting on in the time of a inclusive influenza pandemic.



Statins demean "bad" cholesterol gradation in the blood by blocking the liver's surrender of cholesterol. Statins may further in safe hands the heart by regulating the immune solidify of friends and reducing inflammation. Recent study advise that these effects also serve patients close to serious catching virus such as pneumonia and bacterial infection of the blood.



Because influenza be associated with inflammation and an increased stake of cardiovascular diseases, the anti-inflammatory and immunomodulatory effects of statins may economically also help those with influenza, suggest David Fedson, MD, a retire earlier regulator of medical affairs in go to of a key vaccine originator. If an influenza pandemic perform materialize, statins would have the added talent of person instantly available, divergent influenza vaccines, which must be manufactured after the virus strain is identified.



"It is ample to blemish that the statins/influenza belief is individual that--an idea," Dr. Fedson said. "It wants to be confirmed by rigorous proven studies." Statins wouldn't replace vaccines, he added, because "unlike vaccines, they probably wouldn't preclude influenza virus infection itself." However, if research demonstrate that statins be valuable, "their threat would hilltop appointed be in prevent serious complications and destruction. In edict to do this, they would probably have to be continual through the duration of the illness." Besides being readily available, statins would be relatively on public sale, conspicuously the generic mixture. "As generics, they are already being produced in several surfacing countries and should be available and affordable in almost all countries," Dr. Fedson said. "Keep in be bothered that astonishingly big amounts of statins are produced for tens of millions of cardiovascular disease patients to thrash year globular. For influenza, they probably would be taken for only five to 10 days, and this would not have a major impact on unexciting production and sale levels by the manufacturer." Further research on statins as managing and prophylaxis for pandemic influenza, plus laboratory studies and clinical trial, is requisite, Dr. Fedson said, concluding in his article that statins "could become the only right now available agents to alter the track of what otherwise might become an unprecedented global qualification misfortune." ---------------------------




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