Blood Pressure Vaccine

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The Daily Mail write that the squash could retrieve the singing
of thousands of patients by dropping blood
pressure in the over-hasty morning, "a occurrence when the
level of angiotensin be high and the summit time in rather of
heart attack and strokes". They right to be hear that newsworthy
medication go amiss to combat this difficulty length above all
because society tend to pinch their pills subsequent in the
morning near their breakfast. Other reporters synonym that the
current tablets can have insalubrious loin effects, or that by
development of high blood pressure has
no ostensible symptom, people cause not preserve to their
government regime.

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This parable be base opposed to a gain routine of in 72 adults
that mainly aimed to evaluate the safekeeping of the new vaccine
by equate two contrary dose with a "dummy" shot (placebo). The
pilot safety grades air burgeoning, and the researchers found
that a thorny dose of the vaccine reduced daytime systolic blood
pressure at 14 weeks compare with the model injection.

However, these initial results be obtain in a dismissive secret
code of people who had gentle to pitch feathers high blood pressure, and
who were otherwise active. Larger, longer-term study are needed
in a broader cluster of people to assess long-term safety and to
back up the offering in blood pressure. It will also have need of
to be compared to current blood pressure tablets (in expert those
that target one and the same hormone), and be assess for how
noticeably it can cheapen outcome such as heart attacks.

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What character of test study was this?

This was a dual unsighted randomised controlled testing in people
with high blood pressure (hypertension). This step IIa trial
tested the safety and efficacy of a vaccine (CYT006-AngQb) that
targeted a protein call angiotensin II, which is enmeshed in
regulating blood pressure.

The researchers enrol 72 adults with mild to moderate high blood
pressure (according to World Health Organization criterion -
systolic blood pressure 140-179 mmHg; diastolic blood pressure 90
to 109 mmHg). Other than have hypertension, the participant were
healthy. The researchers incorporated man and women who were
postmenopausal or who had be surgically sterilised. The
participants had to be a moment ago diagnose with hypertension,
or diagnosed once but were not acknowledgment treatment, or on
treatment that could be stopped without cause adverse effects.

The participants were by point in time commit to receiving any a
mock dose (100 microgrammes) of the vaccine, a higher dose (300
microgrammes), or a placebo. To reduce the chance of adverse
dealings, the researchers at most primitive newly give the
participants either the lower dose vaccine or the placebo, and
when no serious adverse events had been observed, people were
randomly allocated to receiving the higher dose.

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What were the results of the study?

Most people receiving the vaccines mature mild provincial
reaction at the scene of the injection (including magnification
and hardening) which went away without treatment. People
receiving the higher dose of the vaccine had vitally more
headache than people in the lower dose and placebo groups. Three
people in the lower dose group and seven people in the higher
dose group experienced mild flu-like symptoms, and these symptoms
were not see in the placebo group. There were five scholarly
adverse events during the trial, two in all of the vaccine groups
and one in the placebo group (the talent of these events is not
report by the study). However, none of these events were judge to
be associated to the treatment received.

Five people reduce out of the study, two in the lower dose group
and three in the higher dose group. The reason for dropping out
included one luggage each of debt of agreement, adverse event
(fainting) after first vaccine injection, development or vertigo
and two cases that were silent.

From the start of the study, the researchers found that the
higher dose of the vaccine (but not the lower dose) reduced mean
daytime systolic blood pressure significantly greater than
placebo. The higher dose also reduced the tide in blood pressure
that is to say usually seen in the early morning compared with
placebo. Neither dose of the vaccine resulted in consequential
modification in nighttime blood pressure, nor was in that any
dissimilarity between the groups in blood pressure measured in
the doctor's office.

What impression did the researchers be a focus for from these
results?

The researchers concluded that the anti-angiotensin vaccine was
not associated with serious side effects, and that the higher
dose of the vaccine reduced daytime blood pressure in people with
mild to moderate hypertension.

What do the NHS Knowledge Service make of this study?

This was a well-designed study that indicate that vaccines may
have a role to play in treat high blood pressure in the proposed.

However, this study mainly aimed to ensconce the safety of the
vaccine in the stumpy tenure, and larger, and longer-term studies
will be needed to further delve into the safety and efficacy of
this vaccine. These studies will also need to investigate the
effects of the vaccine in people with more severe high blood
pressure, and in people who not only have hypertension, but also
other condition worries. The injection may not apply for several
of the groups of people that were excluded by this study, for
model they would must be nearly new vigilantly in people with
kidney problems.

It will also need to be seen how this treatment compare to
current blood pressure tablets that target the same hormone (i.e.
ACE inhibitors and angiotensin II receptor blockers), and to
predilection whether it results in a reduction in outcomes such
as heart attacks.

Links to the headline Hope completed high blood pressure jab. BBC
News, March 07 2008Blood pressure jab 'could save thousands'. The
Daily Telegraph, March 07 2008Jab to stuff high blood pressure.
The Sun, March 07 2008 Links to the science Effect of
immunisation against angiotensin II with CYT006-AngQb on
ambulatory blood pressure: a double-blind, randomised,
placebo-controlled phase IIa study.

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