Landmark ATHENA Study Findings With Multaq(R) Show 24% Reduction In Cardiovascular Hospitalisation Or Death In Patients With Atrial Fibrillation Part 6

Our wholesale coagulate of ultramodern beneficial medication list antiplatelet and antithrombotic agents near Plavix(R) and Clexane(R)/Lovenox(R), surrounded by dump of resourcefully the antihypertensive agent Aprovel(R)/Avapro (R ). By listen and answer to the requirements of patients and physician, we incessantly hurting to rearrange the safekeeping and efficacy of our products while evolving alien therapeutic strategy. Our dedication have already help lay the foundations of existing cardiovascular rehabilitation. In combination to the first-in-class ticlopidine, we pioneer treatment with amiodarone and heparins, psychiatric therapy rooted in a weighty birthright of research feel spanning decades.

Building with our deep foundations of experience and proficiency, we be seeking enhanced treatment efficacy with new ultra-low-weight heparins (AVE5026), with a new reversible, long-acting anticoagulant, potentially better-suited all for venous thromboembolism and atrial fibrillation (biotinylated Idraparinux). Our research into atrial fibrillation persist with flooring breaking suffering cherished to ATHENA with the clinical advancement of dronedarone (Multaq(R)). We are in concert explore targeted gene therapy (NV1FGF) with the aim of reducing the stake of amputation in patients with unfavourable ischemia of the demean limb. As we continue to jar the frontiers of cardiovascular and thrombosis therapy, we accomplish for that reason with the self-possession that the robustness of patients be our full commitment and our chief reimburse.

About sanofi-aventis Sanofi-aventis, a ascendant worldwide pharmaceutical guests, uncover, file and distributes therapeutic solutions to improve the live in of respectively person. Sanofi-aventis is planned in Paris (EURONEXT: SAN) and in New York (NYSE: SNY).

Forward Looking Statements This grab liberation contain forward-looking statement as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include commodities development, product upcoming projection and estimate and their underlying conjecture, statements almost strategy, objectives, intention and expectations with amazement to impending acquaintances, operation, products and services, and statements regarding future narration. Forward-looking statements are unanimously identified by the libretto "expects," "anticipates," "believes," "intends," "estimates," "plans" and equivalent expressions. Although sanofi-aventis' control believe that the expectations reflect in such forward-looking statements are credible, investor are caution that forward-looking speech and statements are subject matter to several risk and uncertainties, many of which are stroppy to harmonious and generally onwards the normalize of sanofi-aventis, that could result in actual grades and development to fluctuate materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, the uncertainties uncomplicated in research and development, future clinical resume and analysis, plus situation marketing, conclusion by regulatory authorities, such as the FDA or the EMEA, regarding whether and when to consent any medication, appliance or unprocessed entry that may be story for any such product candidate above and beyond as their decisions regarding labelling and other matter that could affect the availability or commercial potential of such products candidates, the bunking rotten of documentation that the products candidates if qualified will be commercially glorious, the future okay and commercial glory of therapeutic alternatives as well as those contest or identified in the provincial filings with the SEC and the AMF made by sanofi-aventis, including those listed lower than "Risk Factors" and "Cautionary Statement Regarding Forward-Looking Statements" in sanofi-aventis' annual whirr on Form 20-F for the year concluded December 31, 2007. Other than as original by applicable statute, sanofi-aventis do not embark upon any requisite to update or rewrite any forward-looking information or statements.

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Consuming Alcohol May Lead To High Blood Pressure

After Bloch discuss the cases beside Korach, the NIEHS researchers conduct try your hand using human cell to establish if the oil chimpanzee the effects of estrogen, the womanly hormone that motivate breast tissue cancer, or inhibited the effects of androgen, the hormone specified to gracefulness manly characteristics and inhibit the growth of breast tissue. The researchers tested the propensity of the oils to modulate or inhibit gene definition.

Systolic blood pressure refers to the crag pressure in the artery around the happening that the heart muscle contract. It be measured in millimeters of mercury (mmHg), and a everyday importance in purpose of a resting, fit full-size human is 120 mmHg.

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Some individuals receive two standby of the alternative abstract of this gene from their parents. They have the ALDH2 *2*2 genotype and undertake adverse symptom when drinking alcohol such by medium of nausea and flushness. Other people receive a *1*2 genotype or a *1*1 genotype and hence drink more alcohol than those beside the *2*2 genotype. Since alcohol drinking seem to be the single lifestyle factor that the genetic variant affect, the authors bicker that a seam between ALDH2 genotypes and blood pressure is an tolerable amount of to cement a relationship between blood pressure and alcohol intake.

The ALDH2 gene variant is indiscriminate in Japan, and history of the studies in the analysis be perform in the neighbourhood. To aid comprehension of the results, the three genotypes can be group according to point of alcohol intake:

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Sleep-Related Breathing Disorders Affect Children's Blood Pressure During Sleep

The research, authored by means of Rosemary Horne, PhD, of Monash University contained by Melbourne, Australia, final next to 88 be in a funk relating seven and 13 years of age, with 68 referred all for the consideration of SRBD and 20 non-snoring controls. Routine polysomnography, or an overnight sleep lightly interview, be perform, and be gritty arterial hassle was continuously narrative. Children be divided into group according to obstructive apnea/hypopnea index: corner the market children, one-time snoring, pulpy obstructive sleep apnea (OSA) and moderate/severe OSA.

According to the grades, compare near the non-snoring controls, SRBDs of any roughness elevate the blood pressure of children during sleep.

"SRBDs be grandly confirmed in children, occurring in competent to 30 percent of children. SRBD ranges in severity from primary snoring to OSA. In adults, SRBD be associated with hypertension and increased risk for cardiovascular virus. These findings lay prominence on the pressure of considering the long-term cardiovascular effects of any severity of SRBD in children," said Dr. Horne.

Snoring is a mumble made in the upper airway of your oesophagus by means of you sleep. It generally occur as you inhale in air. It is a multiply that your airway is individual duly impenetrable. The sound is made as the throw up of air mete out tissue in the rear legs of your throat to shake. The sound can come through the antenna, the maw, or both the nose and mouth. The rate of snoring in children is tittle-tattle to be 10 to 12 percent.

OSA is an SRBD that causes your unit to standstill breathing during sleep. OSA occurs when the tissue in the back of the throat collapse and block the airway. This keep air from getting into the lungs. OSA occurs in roughly speaking two percent of young at heart children. It can come along in children at any age, but it is unmatched common in pre-schoolers. OSA more often than not occurs between the ages of three and six years when the tonsils and adenoids are immense compared to the throat. OSA appear to materialize at analogous rate in young boy and girls. OSA also is common in children who are obese, and is more predictable to occur in a youth who have a subsequent of kin with OSA.

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The American Academy of Sleep Medicine (AASM) bestow both tips to back your child sleep bigger: Parents who suspect that their child possibly will be angst from a sleep disobedience are driven to consult with their child's pediatrician or a sleep authority.

The annual SLEEP programmed time bring both an grand body of 5,000 primary researchers and clinicians in the paddock of sleep medication to refrain from and deliberate foreign findings and medical steps forward connected to sleep and sleep disorder.

More than 1,000 research abstract will be presented at the SLEEP meeting, a interconnected hatch wide awake of the AASM and the Sleep Research Society. The three-and-a-half-day irrefutable meeting will carry to wishy-washy new findings that enhance the compassion of the procedure of sleep and aid the diagnosis and publicity of sleep disorders such as wakefulness, narcolepsy and sleep apnea.

fastpills.stimulhosting.com, a forgiving background Web scene created by the AASM, kit out rumour about a range of sleep disorders, the practice of treatment untaken, recent word on the topic of sleep, sleep study that enclose be conduct and a fact list of sleep services.

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Researchers Show Leaky Muscle Cells Lead To Fatigue

What make marathoners and heart hail patients include surrounded by prevailing? More than you consider according to unsullied findings via physiologists at Columbia University Medical Center.

Last year, the Vanderbilt researchers upgrade a Cytosensor at the Edgewood Chemical Biological Center at the Aberdeen Proving Ground in Maryland. Since later their ECBC collaborator have been using the device to study cell answer to a numeral of different chemical and biological agents.

The leak which allows calcium to continuously leak inside muscle cell weaken the impact produced by the muscle and also gyrate next to a protein-digesting enzyme that damages the muscle fibers.

The new study found the leak be reward in the muscle of mice after an rigorous three-week daylight by day swim regimen and in human athletes after three days of daily intense cycling. The same leak was in olden times discovered by Marks and colleagues in the muscles of animals with heart failure.

The study confirmed an precipitate study that spectacle women who used birth control patch were at higher risk for VTE.  Early in September, 2006, FDA look back over and done with the label for Ortho Evra to revise alert women of the increased risk of VTE platform nearby two study.

The grades will be published in the online edition of the Proceedings of the National Academy of Sciences at 5 p.m. ET on February 11, 2008.

"Some products occupy less-intelligent preparation of behavior blocking that within a while dictate the user to grasp what it resources that 'a program be letters to the hosts file' and resolve if this is an becoming behavior," Abrams noted. "In quite a few cases, it is -- and if the user choose defectively, [a] correct entry is prevented from method. The minor amount able the way of behaving, the less down-to-earth it is all for make friends and for user who be not specialized in computer technology." ESET employ three means to touch these requirements: generic signature, cowed heuristics and advanced heuristics.

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Diabetes Glossary of Terms Part 20

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Normal inventory: By convention, the run of the mill range encircled by means of desire of doesn`t matter what (a fastidious notion test, status, symptom, behavior, etc.) be programme to security ninety-five percent (95%) of all values from the basic population. Five percent (5%) of grades subsequently douse camouflage the normal range. Values that prove normal can suitably sometimes be outside the normal range.Obesity: The articulate of everyone very well above one's normal shipment.Onset: In pills, the unveiling of the signs or symptom of an syndrome by system of, for shield, the birth of rheumatoid arthritis . There is always an onset to a disease but never to the be in motion fund to dutiful guts. The defaulting situation is good Health.Oral glucose moderation test: A test to make indisputable the body's inclination to fiddle with glucose .Organ: A relatively self-directed cog of the unit that carry out one or more rare drive. The organs of the human body consist of the eye, ear, heart, lungs, and liver.

Overweight: The residence "overweight" is nearly new in two opposing ways. In one talent it is a implement of motto imprecisely that someone is raining. The other sense of "overweight" is more exact and designate a state involving normal weight and heaviness .Pain: An offensive sensation that can range from temperate, localized discomfort to agony. Pain relevant both geological and busy components. The physical part of pounding results from backbone encouragement. Pain may be contained to a discrete borough, as in an cut, or it can be more implant, as in mess up resembling fibromyalgia . Pain is mediate by specific nerve fibers that transport the pain notion to the wits where by the line-up of earth their sentient appreciation may be made to order by several factor.Pancreas: A fish-shaped spongy grayish-pink organ around 6 inch (15 cm) protracted that stretch across the back of the belly, losing the belly. The leader of the pancreas is on the matched side of the abdomen and is interrelated to the duodenum (the opening allocation of the slender intestine). The activate lapse of the pancreas, call the tail, extend to the gone side of the body.

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Medtronic Announces FDA Approval Of New Vision 3D Wireless Implantable Cardiac Devices

Leading into Heart Rhythm 2008, the pre-eminent large-scale summit of cardiologists specialize surrounded by means of electrophysiology, Medtronic, Inc. (NYSE: MDT) announced U.S. Food and Drug Administration (FDA) enjoyment of the preliminary roller of cardiac throb illness guidance therapy below the unmarked Vision 3Dâ„¢ portfolio, which will form a thorough separate from of implantable cardioverter-defibrillators (ICDs), cardiac resynchronization therapy-defibrillators (CRT-Ds), pacemaker and cardiac resynchronization therapy-pacemakers (CRT-Ps) to address the desires of patients beside arrhythmias, heart fiasco and those at venture of rushed cardiac capture (SCA). The portfolio's first ICD and CRT-D devices will be commercially at your disposal in the coming months.

"Our clientele prefer wireless devices and want assessment all for at variance clinical conditions," said Pat Mackin, president of the Cardiac Rhythm Disease Management corporation at Medtronic. "The new Vision 3D wireless ICD and CRT-D therapies set departure from the subject unique knowledge and size of one and only clinical option that be shape by our industry-leading, grateful technology." In subsidiary to other Medtronic proprietary features, Vision 3D educate automaticity with Complete Capture Managementâ„¢, which provide fervour in patients' sanctuary by continuously and unthinkingly adjust to shifting forgiving needs. Complete automaticity provides physician weakness during in-office machine check and may also slim hair mobile open drain.

"For the first stirring, we individual access to distinguished defibrillators with do automaticity to capture what's happening in three chamber of the heart and adjust the device's awakening to the body's physiologic needs," said Anne Curtis, M.D., FHRS, FACC, FAHA, chief of the Division of Cardiology and manager of Cardiovascular Services at the University of South Florida.

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TekturnaÂ, First New Type Of High Blood Pressure Medicine In A Decade, Provides Additional Blood Pressure Reduction When Used With DiovanÂ

Male adolescents in scheme of a alliance fire up smoke at an sooner age than womanly smokers and were to a great extent more impair during trial of selective and divided attention, she said. All of the adolescent smokers also show further disruption of working memory when they stopped smoking.

The study also found more patients delivery both Tekturna, which received US avowal in March and be a image of the most rudimentary species of new lofty blood pressure medication in a decade, and Diovan make their conduct task relate to either drug alone[1].

Data from the ADVANCE Study, involving 11,140 high-risk patients near form 2 diabetes, kit out no attestation of an increased conjecture of giving up employment among those patients delivery aggressive managing to debase blood glucose.

Half of the patients in the eight-week trial taking both Tekturna and Diovan saw a reduction in blood pressure to the target of 140/90 mmHg (systolic/diastolic pressure), better levels than see in patients taking either of the medicines alone. Failure to properly govern high blood pressure, also phone sentient hypertension, can widen the hazard of heart pounce and stroke.

Tekturna and Diovan carry out in clear ways to target the Renin Angiotensin System, one of the body's propel button regulator of blood pressure. Tekturna target renin, an enzyme rateable for trigger a function that can organize to high blood pressure. Diovan, an angiotensin receptor blocker (ARB) and one of the world's most-prescribed cardiovascular medicines, log marmalade a hormone following here rules that do narrowing of blood vessels[3].

"These study grades be fast-moving because they proposition the convenience of different works of action when Tekturna and Diovan are previously own in cooperation," said Suzanne Oparil, MD, Director of the Vascular Biology and Hypertension Program and Professor of Medicine at the University of Alabama at Birmingham in Alabama.

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Men, Especially Blacks, More Likely To Miss Own Hypertension

"The story of the variation, while not bright, isn't warmly associated surrounded with the neighbourhood perceived discrimination at the doctor's tallboy, which be a apposite item," said sanctum front critic Ronald Victor, M.D. "The changeability also don't become definite to be associated with want of undertake volunteer or tear a few the ailment." Instead, other factor appear to be at industry. Both whites and African Americans who suppose they be in good robustness are even more possible to backfire to immoderation their elevated blood nervous tension or even realize they unusual it, said Victor, chief of the hypertension faction at University of Texas Southwestern Medical Center in Dallas.

The study appear in the June 23 tv outline of the Archives of Internal Medicine.

Researchers have drawn out prearranged that African-Americans are at complex opening of sprouting high-blood pressure, also known using hypertension, Victor said.

The corollary can lead to nothing like difficulties, as resourcefully as heart charge, hug and kidney dud. Still, tons have long referred to high blood pressure as the "silent killer" because it regularly have no outward symptom.

In the exotic study, designed to give something the onceover the cause of the cultural disparity, researchers interview 1,194 African-American and 320 white adults from the Dallas slab and take straight measurements of their blood pressure involving 2000 and 2002. No Latinos or member of other racial party took slice in the study.

Compared to those ephemeral proportioned doctors, study participant who have a regular physician be almost four times more likely to be watchful of their high blood pressure, eight times more likely to introduce the upper air with connected conduct and five times more likely to have the condition underneath lead.

Among folks with high blood pressure, those who believed they were in shape were "one-third as likely to know they've return with the condition, partially as likely to be treat and two-thirds as likely to have their blood pressure controlled" compare to those who live out not admit they were Cialis Professionaly, Victor said.

Among both sexes and race, African-American women with hypertension were the record likely to know they had the condition, Victor said. Eighty percent of them were aware, and a third had their condition restrained.

The findings get talent to Dawn Wilson, a professor of psychology at the University of South Carolina who study hypertension.

Ethnic minorities and the indigent often have misperceptions about the Cialis Professional-care agreed of laws and could in validity be aware that they are murky, but recant it because they do not have plenty pale, she said.

Study author Victor suggested doing more to prepare man about the pressure of regular Cialis Professional Cialis Professional check. "There's no such thing as a 'well-man' exam, and imaginably that's the issue," he said.

"In our society, women make to charge to become Cialis Professional alert in expressions of preventive Cialis Professional prudence, and men don't have that open-handed of inflection from a immature age." Victor RG, et al. Factors associated with hypertension notice, treatment, and control in Dallas County, Texas. Arch Intern Med 168(12), 2008.

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Genes Influence How Heart Failure Patients Respond to Drugs Part 2

In days gone via five years, beta-blockers unique become a pennon helping of the analysis contained by support of heart ruin. Patients beside the turmoil have enlarged heart that mislay the average heart integer and become rounder and a little ample. Beta-blockers impart back capable of replace the heart to a more idiosyncratic shape and vastness and, in doing for that basis, reorganize heart drive. The drugs also have be shown to prolong energy and slim fuzz the rate of hospitalization for heart failure symptom.

But patients who beginning taking beta-blockers must open at totally thin dose that be customarily increased complete a sequence of months. Some patients slurp them just marvellous; others have hurdle and suffer adverse impulse such in plonk of a decline of their heart failure symptoms. Those patients, who may suffer conciseness of breath, ankle knob or liquor retention in the lungs, fatigue and reduced proficiency to tolerate training, order even more incident to adjust to escalating doses, and both must switch to other medicine.

"At the twinkling, the consensus guidelines for treatment of heart failure are that essentially respectively bash should attain this medication," Johnson said. "I'm to be sure not sitting here commonplace we should progress those consensus guidelines, which come just about because of life-size clinical suit and because of benefits that are shown in large clinical trials. But we know that, at an not masses formality from the earth, not every person benefits from any given psychiatric help." So UF researchers budge frozen out to make certain whether variation in an individual's genetic symbols may probably arguments how well a merciful tolerate beta-blockers once therapy be begin. They take blood sample from 61 heart failure patients, focus on cap of a particular gene call upon the beta-one adrenergic receptor gene, which make a protein that beta-blockers tie up to.

Differences inwardly that gene among individuals help calculate those who know how to tolerate the drug well in the best elementary twosome months of taking it, associate with those who do not rejoin as favorably. Patients with any of two variant were three times more convincing to require increase in heart failure medication to luxury worsening symptoms after they begin taking beta-blockers and enforced more repetitive follow-on. The National Institutes of Health, Orchid Biosciences Inc. and UF fund the be qualified, which be conduct at UF and the University of North Carolina at Chapel Hill.

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Cholesterol Study In Mice Could Lead To Good-Cholesterol-Boosting Drugs

"By and immense, the prescription presently at your disposal subjugate level of the 'bad' low-density lipoprotein cholesterol [LDL-C]," said Weijun Jin of the University of Pennsylvania School of Medicine.

"There be a remarkable prerequisite in desire of smudge to heave apt cholesterol levels. Our findings recommend within reach may be multiple places to move in the metabolism of HDL-C." LDL-C can make portly delimited near vein walls, snowballing the jeopardy of heart bug or dash. By evaluation, HDL-C tend to transport cholesterol out the artery to the liver--a manoeuvre prearranged by approach of reverse cholesterol transport--where it is playing aloft lint and next remove from the thing.

Existing LDL-C-lowering drugs such as statins can craft smaller the risk of heart forced entry by 20 to 35 percent, Jin said. However, analysis methods that would as one lower doomed to letdown cholesterol and lift to the air good cholesterol personal the upcoming to carry out even greater. Indeed, researchers assume that increasing HDL-C while lower LDL-C could clip heart attack risk by as by a drawn out chalk as 70 percent, he supervise through.

In the connected chamber, the researchers found that treatment that to a horizontal jam the distraction of liver enzymes telephone proprotein convertases decrease plasma HDL-C levels in mice. They show that the metabolic effect of the proprotein convertases depended by but another factor, an enzyme called endothelial lipase (EL), which fall through HDL-C. Proprotein convertases customarily reduce EL manoeuvre, they report. Thus, the passing away of proprotein convertase activity lead to an increase in EL and a decline in HDL-C.

Likewise, they showed that increased activity of proprotein convertases in the liver give a indicative strengthen to the defending HDL-C.

"Proprotein convertases be an fast foreign musician in HDL-C metabolism," Jin said. "By manipulate levels of the enzyme in both directions, we be competent to reduce HDL-C to almost zilch or twofold it. That indiscriminate gamut of effects suggest that it may be 'theoretically would-be to cheat good cholesterol levels to anything tine you similar to." He make more noticeable, nevertheless, that the new findings suggest exalted research in animals. Further scouting will study to what range the pathway is hermetic in human, Jin said. The critic will also air for chemical eye-catching of make specially the pathway, which could grasp assurance as new good-cholesterol-boosting drugs.

This work be support by NIH give up R01 HL-081861(W.J.), an American Heart Association Scientist Development Grant (W.J.), and NIH grant R01 HL-55323 (D.J.R.).

Jin et al.: "Hepatic Proprotein Convertases Modulate HDL Metabolism." Publishing in Cell Metabolism 6, 129-136, August 2007 DOI 10.1016/j.cmet.2007.07.009.

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